Scalable Process for 4‐(2‐Hydroxy‐2‐methyl)‐ethyl‐benzylamine
The preparation of the title compound has been revisited and improved. Starting from inexpensive cuminonitrile, 4‐(2‐hydroxy‐2‐methyl)‐ethyl‐benzylamine is obtained in a scalable two‐step process with an overall yield of 55%.
Keywords: Catalysis; oxidation; phase transfer
Document Type: Research Article
Affiliations: 1: Chemical Research and Development, Pfizer Inc., La Jolla Labs, San Diego, California, USA 2: Chemical Research and Development, Pfizer Inc., Groton, Connecticut, USA 3: CarboGen Laboratories, AGSchachenallee, Switzerland
Publication date: 01 January 2006
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