Berberineattenuated monocyte adhesion to endothelial cells induced by oxidized lowdensity lipoprotein via inhibition of adhesion molecule expression
Recruitment of monocytes to endothelial cells is important during early stages of atherosclerosis development. This process is predominantly mediated by cellular adhesion molecules, including vascular cell adhesion molecule1 (VCAM1) and intercellular adhesion molecule1 (ICAM1), which
are expressed by activated endothelial cells in response to a number of inflammatory stimuli, including oxidized lowdensity lipoprotein (oxLDL). Previous studies have demonstrated that berberine, a natural extract from Rhizoma coptidis, prevents oxLDLinduced endothelial cellular apoptosis.
However, its effect on the adhesion of monocytes to endothelial cells and the mechanism associated with this process remains unclear. In the present study, berberine was revealed to markedly reduce oxLDLinduced monocyte adhesion to human umbilical vein endothelial cells. In addition, the inhibitory
mechanism of berberine was associated with suppression of adhesion molecule expression, including VCAM1 and ICAM1. Results indicate that berberine plays a protective role in the early stages of atherosclerosis.
Document Type: Research Article
Affiliations: Cardiac Center, The First Affiliated Hospital of Wenzhou Medical College, Zhejiang 325000, P.R. China
Publication date: 01 January 2013
- Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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