In Vitro Antioxidant Activity of Passion Fruit (Passiflora alata) Extract by Different Kinds of Treatment on Rat Liver
Background: Passion fruit is known to be rich in flavonoids and can be an important antioxidant, preventing the oxidative damage. The objective of this study was first to evaluate the antioxidant activity of Passiflora alata fruit extract in the liver of Wistar rats and second to compare
the efficacy of pretreatment or co-treatment of this extract.
Method: Antioxidant activity of Passiflora alata fruit extract was analyzed by lipid peroxidation (TBARS), protein oxidation (carbonyl), Sulfhydryl levels and enzymatic activity of superoxide dismutase (SOD) and of catalase (CAT) against sodium azide damage induced in the liver of Wistar rats.
Results: The pre-treatment extract reduced and/or prevented the lipid peroxidation and protein oxidative damage caused by sodium azide. The co-treatment didn't show any protection at the level of protein oxidation damage, in this case an increase of damage was observed. Sulfhydryl levels increased in all groups. The SOD activity was not significantly different between groups, but the CAT activity increased in the group with co-treatment.
Conclusion: Pre-treatment with passion fruit (Passiflora alata) can be an alternative in reducing oxidative damage in the liver.
Method: Antioxidant activity of Passiflora alata fruit extract was analyzed by lipid peroxidation (TBARS), protein oxidation (carbonyl), Sulfhydryl levels and enzymatic activity of superoxide dismutase (SOD) and of catalase (CAT) against sodium azide damage induced in the liver of Wistar rats.
Results: The pre-treatment extract reduced and/or prevented the lipid peroxidation and protein oxidative damage caused by sodium azide. The co-treatment didn't show any protection at the level of protein oxidation damage, in this case an increase of damage was observed. Sulfhydryl levels increased in all groups. The SOD activity was not significantly different between groups, but the CAT activity increased in the group with co-treatment.
Conclusion: Pre-treatment with passion fruit (Passiflora alata) can be an alternative in reducing oxidative damage in the liver.
Keywords: Passiflora alata; oxidative stress; passion fruit; polyphenols; sodium azide
Document Type: Research Article
Publication date: 01 March 2018
- The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.
The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents. - Editorial Board
- Information for Authors
- Subscribe to this Title
- Ingenta Connect is not responsible for the content or availability of external websites
Receive new issue alert- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content