Endothelial Cell Targeted Molecular Imaging in Tumor Angiogenesis: Strategies and Current Status
Angiogenesis plays crucial roles in tumor growth, progression and metastasis. Non-invasive in vivo imaging of tumor neovasculature is a fundamental prerequisite for effective therapeutic intervention, particularly anti-angiogenic treatment regimens. Emerging molecular imaging techniques
now allow recognition of cellular/molecular processes before gross pathological changes, leading to better understanding of fundamental biological processes of tumor angiogenesis. In this review, we will summarize recent progresses on molecular imaging of attractive biochemical epitopes in
tumor angiogenesis, especially the endothelial cell targets-based imaging probes.
Keywords: Angiogenesis; Contrast agent; Molecular imaging; Tumor; Vascular imaging
Document Type: Research Article
Publication date: 01 October 2013
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