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Home / Current Pharmaceutical Design, Volume 9, Number 32

Runx2/Cbfa1: A Multifunctional Regulator of Bone Formation

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Authors: Lian, J. B.; Stein, G. S.

Source: Current Pharmaceutical Design, Volume 9, Number 32, 2003, pp. 2677-2685(9)

Publisher: Bentham Science Publishers

DOI: https://doi.org/10.2174/1381612033453659

Runx2/Cbfa/AML3 is a member of the runt homology domain family of transcription factors, essential for osteoblast differentiation and bone formation. Defining the molecular mechanisms by which Runx2 can function as a master regulatory gene for activating the program of osteoblastogenesis has provided novel insights for transcriptional regulation of tissue-specific genes. Regulation of Runx expression has the potential to serve as a basis for the design of novel therapeutic strategies for promoting bone formation. Here we review the unique properties of Runx2 that mediate several key functions necessary for regulating skeletogenesis, controlling osteoblast growth and differentiation, and integrating the complex pathways required for bone formation and turnover.

Keywords: bmp; bone development; nuclear targeting; osteoblast differentiation; osteoporosis; runx coregulatory proteins; runx2; subnuclear domains; transcriptional complexes; transcriptional control of bone formation

Document Type: Review Article

Affiliations: Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

Publication date: 01 December 2003

More about this publication?
  • Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

    Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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