Cell-dependent function of HIV-1 Vif for virus replication (Review).
It has been well established that the Vif protein of human immunodeficiency virus type 1 (HIV-1) acts late in the viral life cycle and increases the infectivity of the progeny virions in a producer cell-dependent manner. The virions produced in the absence of Vif in non-permissive cells
(Delta Vif) are defective for a step(s) before and/or during reverse transcription. In this review, the functional and structural analyses of these virions including our new data are summarized.
Document Type: Research Article
Affiliations: Department of Virology, The University of Tokushima School of Medicine, Tokushima 770-8503, Japan.
Publication date: 01 May 1999
- The International Journal of Molecular Medicine is a monthly, peer-reviewed journal devoted to the publication of high quality studies related to the molecular mechanisms of human disease. The journal welcomes research on all aspects of molecular and clinical research, ranging from biochemistry to immunology, pathology, genetics, human genomics, microbiology, molecular pathogenesis, molecular cardiology, molecular surgery and molecular psychology.
The International Journal of Molecular Medicine aims to provide an insight for researchers within the community in regard to developing molecular tools and identifying molecular targets for the diagnosis and treatment of a diverse number of human diseases. - Editorial Board
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