Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-24T10:22:27.615Z Has data issue: false hasContentIssue false
  • English
  • Français

Voluntary ingestion of buprenorphine in mice

Published online by Cambridge University Press:  01 January 2023

KR Jacobsen ,
O Kalliokoski ,
J Hau  and
KSP Abelson
KR Jacobsen*
Affiliation:
Department of Experimental Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark
O Kalliokoski
Affiliation:
Department of Experimental Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark
J Hau
Affiliation:
Department of Experimental Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark
KSP Abelson
Affiliation:
Department of Experimental Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark Department of Neuroscience, Division of Comparative Medicine, Uppsala University, Uppsala, Sweden
*
* Contact for correspondence and requests for reprints: kiroja@sund.ku.dk
Get access Rights & Permissions [Opens in a new window]

Abstract

Buprenorphine is a widely used analgesic for laboratory rodents. Administration of the drug in a desirable food item for voluntary ingestion is an attractive way to administer the drug non-invasively. However, it is vital that the animals ingest the buprenorphine-food-item mix as desired. The present study investigated how readily female and male mice (Mus musculus) of two different strains consumed buprenorphine mixed in a commercially available nut paste (Nutella®), and whether variation between genders and strains would affect the subsequent serum concentrations of buprenorphine. Buprenorphine at different concentrations mixed in Nutella® was given to male and female C57BL/6 and BALB/c mice in a complete cross-over study. Pure Nutella® or buprenorphine (1.0-3.0 mg kg−1 bodyweight [bw]) mixed in 10 g kg−1 bw Nutella® were given to the mice at 1500h. The mice were video recorded until the next morning, when blood was collected by submandibular venipuncture. The concentration of buprenorphine in the Nutella® mix did not affect the duration of ingestion in any of the groups. However, female mice consumed the Nutella® significantly faster than males. Repeated exposure significantly reduced the start time of voluntary ingestion, but not the duration of eating the mixture. These differences did not however affect the serum concentration of buprenorphine measured 17 h post administration.

Keywords

analgesiaanimal welfarebuprenorphinemicerefinementvoluntary ingestion
Type
Research Article
Information
Animal Welfare , Volume 20 , Issue 4 , November 2011 , pp. 591 - 596
Copyright
© 2011 Universities Federation for Animal Welfare

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Archer, J 1977 Sex-differences in emotional behavior of laboratory mice. British Journal of Psychology 68: 125–131CrossRefGoogle ScholarPubMed
Bolivar, VJ and Flaherty, L 2004 Genetic control of novel food preference in mice. Mammalian Genome 15: 193–198CrossRefGoogle ScholarPubMed
Brewster, D, Humphrey, MJ and McLeavy, MA 1981 The systemic bioavailability of buprenorphine by various routes of administration. Journal of Pharmacy and Pharmacology 33: 500–506CrossRefGoogle ScholarPubMed
Clark, JA, Myers, PH, Goelz, MF, Thigpen, JE and Forsythe, DB 1997 Pica behavior associated with buprenorphine administration in the rat. Laboratory Animal Science 47: 300–303Google ScholarPubMed
Cooper, DM, Hoffman, W, Wheat, N and Lee, HY 2005 Duration of effects on clinical parameters and referred hyperalgesia in rats after abdominal surgery and multiple doses of analgesic. Comparative Medicine 55: 344–353Google ScholarPubMed
Elmer, GI, Pieper, JO, Negus, SS and Woods, JH 1998 Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests. Pain 75: 129–140CrossRefGoogle Scholar
Flecknell, PA 1984 The relief of pain in laboratory animals. Laboratory Animals 18: 147–160CrossRefGoogle ScholarPubMed
Flecknell, PA 2001 Analgesia of small mammals. Veterinary Clinics of North America: Exotic Animal Practice 4: 47–56Google ScholarPubMed
Flecknell, PA 2009 Laboratory Animal Anaesthesia, Third Edition. Academic Press: USAGoogle Scholar
Flecknell, PA, Roughan, J and Stewart, R 1999 Use of oral buprenorphine (‘buprenorphine jello’) for post-operative analgesia in rats: a clinical trial. Laboratory Animals 33: 169–174CrossRefGoogle Scholar
Forgie, ML, Beyerstein, BL and Alexander, BK 1988 Contributions of taste factors and gender to opioid preference in C57Bl and Dba mice. Psychopharmacology 95: 237–244CrossRefGoogle ScholarPubMed
Frick, KM and Gresack, JE 2003 Sex differences in the behavioral response to spatial and object novelty in adult C57BL/6 mice. Behavioral Neuroscience 117: 1283–1291CrossRefGoogle ScholarPubMed
Gades, NM, Danneman, PJ, Wixson, SK and Tolley, EA 2000 The magnitude and duration of the analgesic effect of morphine, butorphanol, and buprenorphine in rats and mice. Contemporary Topics in Laboratory Animal Science 39: 8–13Google ScholarPubMed
Goldkuhl, R, Carlsson, HE, Hau, J and Abelson, KSP 2008 Effect of subcutaneous injection and oral voluntary ingestion of buprenorphine on post-operative serum corticosterone levels in male rats. European Surgical Research 41: 272–278CrossRefGoogle ScholarPubMed
Goldkuhl, R, Hau, J and Abelson, KSP 2010 Effects of voluntarily-ingested buprenorphine on plasma corticosterone levels, body weight, water intake, and behaviour in permanently catheterised rats. In Vivo 24: 131–135Google ScholarPubMed
Guhad, FA and Hau, J 1996 Salivary IgA as a marker of social stress in rats. Neuroscience Letters 216: 137–140CrossRefGoogle ScholarPubMed
Hawkins, P 2002 Recognizing and assessing pain, suffering and distress in laboratory animals: a survey of current practice in the UK with recommendations. Laboratory Animals 36: 378–395CrossRefGoogle ScholarPubMed
Hedenqvist, P and Hellebrekers, LJ 2003 Laboratory animal analgesia, anesthesia, and euthanasia. In: Hau, J and van, Hoosier Jr (eds) Handbook of Laboratory Animal Science, Essential Principles and Practices pp 413. CRC Press: USAGoogle Scholar
Huang-Brown, KM and Guhad, FA 2002 Chocolate, an effective means of oral drug delivery in rats. Lab Animal 31: 34–36Google ScholarPubMed
Kalliokoski, O, Jacobsen, KR, Hau, J and Abelson, KSP 2011 Serum concentrations of buprenorphine after oral and parenteral administration in male mice. The Veterinary Journal 187(2): 251–254CrossRefGoogle ScholarPubMed
Kohn, DF, Martin, TE, Foley, PL, Morris, TH, Swindle, MM, Vogler, GA and Wixson, SK 2007 Guidelines for the assessment and management of pain in rodents and rabbits. Journal of the American Association for Laboratory Animal Science 46: 97–108Google ScholarPubMed
Leach, MC, Forrester, AR and Flecknell, PA 2010 Influence of preferred foodstuffs on the antinociceptive effects of orally administered buprenorphine in laboratory rats. Laboratory Animals 44: 54–58CrossRefGoogle ScholarPubMed
Liles, JH and Flecknell, PA 1992 The effects of buprenorphine, nalbuphine and butorphanol alone or following halothane anaesthesia on food and water consumption and locomotor movement in rats. Laboratory Animals 26: 180–189Google ScholarPubMed
Liles, JH and Flecknell, PA 1993 The effects of surgical stimulus on the rat and the influence of analgetic treatment. British Veterinary Journal 149: 515–525CrossRefGoogle Scholar
Liles, JH, Flecknell, PA, Roughan, J and Cruz-Madorran, I 1998 Influence of oral buprenorphine, oral naltrexone or morphine on the effects of laparotomy in the rat. Laboratory Animals 32: 149–161CrossRefGoogle ScholarPubMed
Martin, LBE, Thompson, AC, Martin, T and Kristal, MB 2001 Analgesic efficacy of orally administered buprenorphine in rats. Comparative Medicine 51: 43–48Google ScholarPubMed
Petersen, S 1976 Temporal pattern of feeding over estrous-cycle of mouse. Animal Behaviour 24: 939–955CrossRefGoogle ScholarPubMed
Roughan, JV and Flecknell, PA 2002 Buprenorphine: a reappraisal of its antinociceptive effects and therapeutic use in alleviating postoperative pain in animals. Laboratory Animals 36: 322–343CrossRefGoogle ScholarPubMed
Roughan, JV and Flecknell, PA 2004 Behaviour-based assessment of the duration of laparotomy-induced abdominal pain and the analgesic effects of carprofen and buprenorphine in rats. Behavioural Pharmacology 15: 461–472CrossRefGoogle ScholarPubMed
Russell, WMS and Burch, RL 1959 The Principles of Humane Experimental Technique, Special 1992 Edition. UFAW: Wheathampstead, UKGoogle Scholar
Sclafani, A 2006 Enhanced sucrose and polycose preference in sweet ‘sensitive’ (C57BL/6J) and ‘subsensitive’ (129P3/J) mice after experience with these saccharides. Physiology & Behavior 87: 745–756CrossRefGoogle Scholar
Sclafani, A 2007 Fat and sugar flavor preference and acceptance in C57BL/6J and 129 mice: Experience attenuates strain differences. Physiology & Behavior 90: 602–611CrossRefGoogle ScholarPubMed
Sclafani, A, Hertwig, H, Vigorito, M and Feigin, MB 1987 Sex-differences in polysaccharide and sugar preferences in rats. Neuroscience & Biobehavioral Reviews 11: 241–251CrossRefGoogle ScholarPubMed
Thompson, AC, DiPirro, JM, Sylvester, AR, Martin, LBE and Kristal, MB 2006 Lack of analgesic efficacy in female rats of the commonly recommended oral dose of buprenorphine. Journal of the American Association for Laboratory Animal Science 45: 13–16Google ScholarPubMed
Thompson, AC, Kristal, MB, Sallaj, A, Acheson, A, Martin, LBE and Martin, T 2004 Analgesic efficacy of orally administered buprenorphine in rats: methodologic considerations. Comparative Medicine 54: 293–300Google ScholarPubMed
Valenstein, ES, Cox, VC and Kakolews, JW 1967 Further studies of sex differences in taste preferences with sweet solutions. Psychological Reports 20: 1231–1234CrossRefGoogle Scholar
Wade, GN and Zucker, I 1969 Hormonal and developmental influences on rat saccharin preferences. Journal of Comparative and Physiological Psychology 69: 291–300CrossRefGoogle ScholarPubMed
Zucker, I 1969 Hormonal determinants of sex differences in saccharin preference, food intake and bodyweight. Physiology & Behavior 4: 595–602CrossRefGoogle Scholar