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E-cigarette and Nicotine Inhaler Use: 6-month Follow-Up Crossover Trial

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Objectives: Determine subsequent use and cessation behaviors during the 6 months following a 3-day trial period of nicotine inhaler and e-cigarette. Methods: The initial pilot study included 41 daily cigarette smokers naïve to the e-cigarette or nicotine inhaler. Participants trialed the e-cigarette and nicotine inhaler each over a 3-day period, and were subsequently followed-up. At 6 months, 31 of 41 baseline participants (76%) completed follow-up. Measures included subsequent use of products (eg, e-cigarette, cessation medications), cessation methods (eg, quitline, counseling), quit attempts and success over the 6-months. Results: During the 6-month follow-up period, 19/31 participants (61%) used the e-cigarette while only 7/31 (23%) used any FDA-approved cessation medication. Overall, 18/31 participants (58%) made a quit attempt during the 6-months. Of those, 13/18 (72%) used an e-cigarette during follow-up while only 7/18 (39%) used cessation medications. The overall cessation rate at follow-up, per intent-to-treat, was 3/41 participants (7.3%). E-cigarette use was highest among Whites, those married/in a relationship, and those previously using cessation medications. Conclusions: After a 3-day sampling period, current smokers used e-cigarettes at higher rates than cessation medications during the subsequent 6 months, even among those attempting to quit.
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Document Type: Research Article

Publication date: January 1, 2016

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  • Tobacco Regulatory Science (Electronic ISSN 2333-9748) is a rigorously peer-reviewed online scientific journal for the dissemination of research relevant to the regulation of tobacco products. The journal content includes a broad array of research domains, including chemistry, biology, behavior, community, and population-level surveillance and epidemiology, as well as knowledge syntheses (eg, meta-analyses or state-of-the-art reviews) and analytic modeling. All articles describe the policy relevance of the research outcomes. Given the global nature of tobacco regulation, particularly as a result of international and national policies, Tobacco Regulatory Science publishes high quality research that is relevant to global regulatory needs and requirements. Tobacco Regulatory Science is published electronically 6 times per year.
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