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Open Access Call to Establish Constituent Standards for Smokeless Tobacco Products

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Objectives: To summarize evidence supporting the establishment of constituent standards for smokeless tobacco products. Methods: This overview presents data on the sources and levels of several important carcinogens and toxicants in smokeless tobacco products, as well as biomarker-based and epidemiological studies of the relationships between the levels of these constituents in smokeless tobacco products and the levels of exposure and cancer risk in users. Results: The summarized evidence demonstrates feasibility of implementation of standards for the levels of toxic and carcinogenic constituents in smokeless tobacco products and supports the likelihood of public health benefit from the establishment of such standards. Conclusions: It is highly recommended that the US Food and Drug Administration strongly consider establishing constituent standards for smokeless tobacco products.

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Document Type: Research Article

Publication date: January 1, 2016

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  • Tobacco Regulatory Science (Electronic ISSN 2333-9748) is a rigorously peer-reviewed online scientific journal for the dissemination of research relevant to the regulation of tobacco products. The journal content includes a broad array of research domains, including chemistry, biology, behavior, community, and population-level surveillance and epidemiology, as well as knowledge syntheses (eg, meta-analyses or state-of-the-art reviews) and analytic modeling. All articles describe the policy relevance of the research outcomes. Given the global nature of tobacco regulation, particularly as a result of international and national policies, Tobacco Regulatory Science publishes high quality research that is relevant to global regulatory needs and requirements. Tobacco Regulatory Science is published electronically 6 times per year.
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