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The Story of Nitric Oxide: From Rascally Radical to Miracle Molecule

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ONCE CONSIDERED AN environmental nuisance at best and a dangerous poison at worst, nitric oxide (NO) has been discovered to be an important biologic messenger, sending a shock wave through the scientific community. This article briefly reviews the discovery of NO as a regulator of vascular muscle tone and describes important events on its road to fame. The application of inhaled NO (iNO) for the treatment of hypoxic respiratory failure in neonates is discussed.

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Document Type: Research Article

Publication date: July 1, 2004

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