Skip to main content

Open Access Effects of a newly designed paediatric pulmonary heart valve on hemodynamic function

Congenital heart disease is one of the most common types of birth defect. If there is an obstruction of the right ventricular outflow tract, it is often necessary to provide a reconstruction of this outflow tract which is normally performed in the neonatal period. However, in Japan there is no commercially-available prosthetic valve of the appropriate size. Senior Assistant Professor Kenji Suzuki is a paediatric cardiac surgeon based within the Nippon Medical School Musashikosugi Hospital, Japan, who is working to develop a pulmonary valve prosthesis in the paediatric field. He and his team are working to develop a new design of pulmonary valve prosthesis that avoids dysfunction such as thrombus formation and reduced mobility of valve leaflets and the researchers are investigating the effects of a newly designed paediatric pulmonary heart valve on hemodynamic function. To do this, the team will construct a circulatory simulator that mimics the right heart system and measure the right ventricular pressure and pulmonary artery pressure waveform, which will enable them to calculate the regurgitation rate. The researchers will observe valve leaflet motion by video recording. In preliminary experiments, Suzuki and the team have already shown that the regurgitation rate and pressure gradient are lower than those of the prosthetic valve they previously developed and, looking ahead, the researchers plan to gather more data and fine-tune the structure.

Keywords: ARTIFICIAL VALVES; CONGENITAL HEART DISEASE; HEMODYNAMIC FUNCTION; PAEDIATRIC PULMONARY HEART VALVE; PROSTHETIC VALVE; PULMONARY VALVE PROSTHESIS

Document Type: Research Article

Affiliations: Nippon Medical School, Japan

Publication date: March 1, 2022

More about this publication?
  • Impact is a series of high-quality, open access and free to access science reports designed to enable the dissemination of research impact to key stakeholders. Communicating the impact and relevance of research projects across a large number of subjects in a content format that is easily accessible by an academic and stakeholder audience. The publication features content from the world's leading research councils, policy groups, universities and research projects. Impact is published under a CC-BY Creative Commons licence.

  • Subscribe to this Title
  • Terms & Conditions
  • Disseminating research in Impact
  • Information about Impact
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content