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Idiopathic Granulomatous Mastitis: In Search of a Therapeutic Paradigm

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Idiopathic granulomatous mastitis, also known as idiopathic granulomatous lobular mastitis, is a benign breast lesion that represents both a diagnostic and therapeutic dilemma. We report two cases of granulomatous mastitis recently evaluated and managed at our institution. To better understand this rare disease, we analyzed treatment outcomes in reported cases of granulomatous mastitis. One hundred sixteen cases were subsequently analyzed. Primary management strategies included observation (n = 9), steroids (n = 29), partial mastectomy (n = 75), and mastectomy (n = 3). Success rates with each treatment were observation, 56 per cent; steroids, 42 per cent; partial mastectomy, 79 per cent; and mastectomy, 100 per cent. Based on this analysis, we propose a clinically useful algorithm for both workup and management of these challenging cases.
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Document Type: Research Article

Affiliations: 1: From theDepartment of Surgery, Division of Surgical Oncology and the Departments of 2: Pathology and 3: Radiology, University of Florida, Gainesville, Florida

Publication date: August 1, 2007

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