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Multiple Indomethacin-Induced Jejunal Ulcerations with Perforation: A Case Report with Histology

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Gastric and duodenal inflammation and ulceration are well-known complications of nonsteroidal anti-inflammatory (NSAID) usage. However, small bowel ulceration and perforation secondary to NSAID use is uncommon and has rarely been reported in the literature. We describe a perforated jejunal ulcer that developed in a patient using indomethacin for treatment of ankylosing spon-dylitis. We performed a literature review of NSAID-induced small bowel injury and compared the histology of NSAID-related injury with more familiar causes of small bowel perforation.
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Document Type: Research Article

Affiliations: From the Department of General and Vascular Surgery, Gundersen Lutheran, La Crosse, Wisconsin

Publication date: April 1, 2007

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