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Open Access TOP-N53: A Clinical Drug Candidate for the Treatment of Non-healing Wounds

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This article is Open Access under the terms of the Creative Commons CC BY-NC licence.

Chronic non-healing wounds impose a huge burden on patients and health care providers. In spite of improvements in standards of care there are no effective and safe treatments that promote new tissue formation and wound closure in ailments such as diabetic foot ulcer, pressure ulcer, venous leg ulcer or digital ulcer in systemic sclerosis. Endothelial dysfunction, which associates with impaired endogenous nitric oxide formation is assumed to be a main disease mechanism in chronic, non-healing wounds in diabetic and elderly patients as well as in digital ulcers in systemic sclerosis. Topadur Pharma has invented small molecular weight nitric oxide-releasing PDE5 inhibitors, which by modulating a key enzyme system of intracellular signaling may address chronic non-healing wounds. The promising first drug candidate TOP-N53 is currently in early clinical development. Here we describe for the first time the design of TOP-N53 and the synthesis of the clinical GMP batch.
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Keywords: DIABETIC FOOT ULCER; DIGITAL ULCER; MICROCIRCULATION; NITRIC OXIDE; PHOSPHODIESTERASE-5; PRESSURE ULCER; REGENERATIVE MEDICINE; SOLUBLE GUANYLATE CYCLASE; TOP-52; TOP-N53; WOUND HEALING

Document Type: Research Article

Affiliations: 1: Topadur Pharma AG, Grabenstrasse 11A, CH-8952 Schlieren, Switzerland;, Email: [email protected] 2: Topadur Pharma AG, Grabenstrasse 11A, CH-8952 Schlieren, Switzerland

Publication date: October 1, 2020

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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