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Open Access Transforming Olefins into Dinucleophiles

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This article is Open Access under the terms of the Creative Commons CC BY-NC-ND licence.

Herein we present the first example of a three-component dicarbofunctionalization of olefins under reductive conditions. Our strategy takes advantage of nickel catalysis to add aryl and alkyl groups across the double bond with remarkable selectivity. The reaction shows broad functional group compatibility and more importantly, it proves to be general in terms of the alkenes that can be functionalized compared to previous dicarbofunctionalization methods. Initial control experiments reveal different activation modes for both electrophiles and the involvement of alkyl radicals throughout the reaction.

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Keywords: CROSS-COUPLING; DICARBOFUNCTIONALIZATION; NICKEL CATALYSIS; TDAE

Document Type: Research Article

Affiliations: 1: Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland 2: Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich. [email protected]

Publication date: April 1, 2018

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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