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Open Access Automated Microscopy and High Content Screens (Phenotypic Screens) in Academia Labs

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Imaged-based screening has been developing extremely quickly in the past 10 years. Academic institutes quickly realized that the discovery capacity of this technology was huge, allowing the automatic detection and quantification of complex cell phenotypes. Associated with chemical or genetic perturbations, high content screening is the method of choice for a deep system biology analysis. The evolution of high-content screening is mainly due to the recent progress in the development of fast and high quality automated imagers and of a plethora of new very bright fluorescent markers, so that almost any cellular element can be seen and imaged. In this paper we review and summarize the major steps in the development of an image-based screening project.

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Keywords: HIGH-CONTENT SCREENING; IMAGE-BASED SCREENING

Document Type: Research Article

Affiliations: 1: ACCESS-Geneva, NCCR Chemical-Biology, Department of Biochemistry, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland. [email protected] 2: ACCESS-Geneva, NCCR Chemical-Biology, Department of Biochemistry, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland. [email protected]

Publication date: 01 December 2016

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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