Skip to main content
padlock icon - secure page this page is secure

Open Access Taming Hypervalent Bonds and Strained Rings for Catalysis and Synthesis

Download Article:
(PDF 432.4 kb)
Improving the synthesis of complex organic molecules is essential for progress in many fields such as medicine, agrochemicals or materials. Since 2007, our laboratory has been focusing on the development of non-classical bond disconnections based on the use of small, energy-loaded organic molecules: hypervalent iodine reagents and strained rings. In this overview article, we report our progress since 2011 in these areas. The use of cyclic hypervalent iodine reagents has been extended to the C2-selective alkynylation of indoles, the domino cyclization alkynylation of allenes, the alkynylation of thiols and the azidation of carbonyl compounds. Amino-substituted aminocyclopropanes and aminocyclobutanes were used in [3+2] and [4+2] annulations to access nitrogen-rich building blocks, including nucleoside analogues. The first example of dynamic kinetic [3+2] annulation of aminocyclopropanes with both enol ethers and aldehydes was also reported.

53 References.

No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Affiliations: 1: Ecole Polytechnique Fédérale de Lausanne Laboratory of Catalysis and Organic Synthesis EPFL SB ISIC LCSO BCH 4306 CH-1015 Lausanne, Switzerland 2: Ecole Polytechnique Fédérale de Lausanne Laboratory of Catalysis and Organic Synthesis EPFL SB ISIC LCSO BCH 4306 CH-1015 Lausanne, Switzerland. [email protected]

Publication date: August 1, 2014

More about this publication?
  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Information for Advertisers
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more