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Open Access Non-destructive Localization and Identification of Active Pharmaceutical Compounds by Raman Chemical Imaging

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Raman spectroscopy is a powerful and non-destructive technique for chemical and structural identification. Based on inelastic scattering of laser light by molecular vibrations, the analysis can be localized on a microscopic area when combined with a microscope. Thus, by moving the sample under the microscope objective and recording a Raman spectrum at each point, a map of the intensity of specific Raman bands can be generated, effectively creating a chemical image of the sample at the microscale. Here, we present an application of this technique for identifying and localizing active pharmaceutical ingredients in a polymer matrix.

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Keywords: ACTIVE PHARMACEUTICAL INGREDIENTS (API); CHEMICAL IMAGING; POLYMER MICROPARTICLES; RAMAN SPECTROSCOPY

Document Type: Research Article

Affiliations: Ecole d'ingénieurs et d'architectes de Fribourg (EIA-FR), Institut des Technologies Chimiques (ChemTech), Boulevard de Pérolles 80, CH-1705 Fribourg, Switzerland

Publication date: December 1, 2013

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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