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Open Access Bachem – Insights into Peptide Chemistry Achievements by the World's Leading Independent Manufacturer of Peptides

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The Swiss fine chemicals company Bachem, pioneer and specialist in the chemical synthesis of peptides, has also become an internationally leading manufacturer of peptide active pharmaceutical ingredients (APIs). In response to increasing demands in scale and purity, Bachem's research efforts centered on the chemistry involved in solid-phase peptide synthesis and the production of the required amino acid derivatives with the aim of a continuous improvement of the technology. The resulting optimized protocols together with high-throughput equipment enabled us to manufacture long peptide APIs and, more recently, even pharma-grade glycoproteins in industrial scale.

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Keywords: ACTIVE PHARMACEUTICAL INGREDIENTS; LARGE-SCALE PEPTIDE MANUFACTURING; PROCESS DEVELOPMENT; SIDE REACTIONS; SOLID-PHASE PEPTIDE SYNTHESIS

Document Type: Research Article

Affiliations: Bachem AG, Hauptstr. 144, CH-4416 Bubendorf, Switzerland

Publication date: December 1, 2013

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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