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Open Access New Insights in Pharmaceutical Analysis

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The research unit of pharmaceutical analytical chemistry (PAC) has been active in the field of separation sciences for many years. Liquid chromatography (LC) and its latest improvements such as ultra-high performance chromatography (UHPLC) and supercritical fluid chromatography (SFC) are deeply and thoroughly studied, from a fundamental viewpoint to its various application capabilities. Electro-driven separations such as capillary electrophoresis (CE) are also a major field of interest, especially for macromolecules, and low cost. All these techniques are investigated with various detection modes including mass spectrometry (MS) for various applications where high sensitivity and selectivity is needed. Extracting the relevant information from the overwhelming amount of data generated by modern analytical platforms has become an important issue for knowledge discovery in various research fields. The appropriate treatment of such data is therefore of crucial importance to provide valuable information. Numerous works in our research group have demonstrated the usefulness of statistical and mathematical methodologies to improve quality of the results. Therefore, well-established chemometric approaches (e.g. design of experiments, multivariate data analysis, etc.) are implemented to optimize the analytical process from method development to data analysis.

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Keywords: CAPILLARY ELECTROPHORESIS; CHEMOMETRICS; FAST ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLOMICS; TOXICOLOGICAL ANALYSIS

Document Type: Research Article

Affiliations: 1: Research Unit of Pharmaceutical Analytical Chemistry, School of Pharmaceutical Sciences, Geneva-Lausanne, University of Geneva, 20 bd d'Yvoy CH-1211 Geneva 4, Switzerland 2: Research Unit of Pharmaceutical Analytical Chemistry, School of Pharmaceutical Sciences, Geneva-Lausanne, University of Geneva, 20 bd d'Yvoy CH-1211 Geneva 4, Switzerland. [email protected]

Publication date: May 1, 2012

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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