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Open Access How to Increase the Safety and Efficacy of Compounds against Neurodegeneration? A Multifunctional Approach

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Successful drug design requires not only the detailed knowledge of the pharmacokinetic and pharmacodynamic profiles of the drug candidate portfolio but also a thorough documentation of the possible toxic effects on humans and the environment. Thus, experimental and computational strategies able to measure or predict specific profiles of designed compounds related to their potential toxicity are highly desired. Moreover, a strategy to avoid toxic effects thus enhancing the potential efficacy of drug candidates is of great interest. To fulfil this aim, the pharmacochemistry research unit at the EPGL has recently developed and improved methodologies that detect the potential human health and environmental hazards of compounds active against neurodegeneration at an early stage. A three-step strategy is presented herein. In particular, i) an alternative index to model the bioconcentration of chemicals in the environment was determined; ii) the antioxidant activity of chemical species against free radicals was evaluated. Moreover, since antioxidants play a key role in both toxicity prevention and neuroprotection, iii) the potential interaction of such compounds with enzymatic targets involved in the neurodegenerative cascade was investigated in silico.

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Keywords: ANTIOXIDANT ACTIVITY; BIOCONCENTRATION; HDAC; NEURODEGENERATION

Document Type: Research Article

Affiliations: 1: School of Pharmaceutical Sciences University of Geneva, University of Lausanne Pharmacochemistry Quai Ernest-Ansermet 30 CH-1211 Geneva 4, Switzerland 2: School of Pharmaceutical Sciences University of Geneva, University of Lausanne Pharmacochemistry Quai Ernest-Ansermet 30 CH-1211 Geneva 4, Switzerland. [email protected]

Publication date: May 1, 2012

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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