Skip to main content
padlock icon - secure page this page is secure

Open Access Chromatographic Fingerprinting Coupled with Chemometrics for Quality Control of Traditional Chinese Medicines

Download Article:
(PDF 696.4 kb)
The holistic system of traditional Chinese medicine (TCM) is reflected by the integrity of the ingredients contained in herbal medicines, which creates a challenge in establishing quality control standards for raw materials and the standardization of finished herbal drugs because no single component contributes to the total efficacy. Thus, the chromatographic fingerprinting technique of TCM has proved to be a comprehensive strategy for assessing the intact quality of herbal medicine, since the origin of the herbal medicines could be identified and classified based on so-called phytoequivalence. On the other hand, chromatographic fingerprinting is essentially a high-throughput technique and an integral tool to explore the complexity of herbal medicines. In order to further control the comprehensive quality of TCMs, some strategies are proposed to trace the chemical changes of chromatographic fingerprints both in product processing and/or after their administration by modern chromatographic techniques and chemometrics. Combined with the techniques developed in systems biology, it seems also possible to reveal the working mechanism of TCMs and to further control their intrinsic quality.

99 References.

No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Affiliations: 1: Research Center of Modernization of Chinese Medicines Central South University Changsha 410083, China. [email protected] 2: Xinjiang Uygur Autonomous Region Institute for Food and Drug Control Urumqi, 830004, China

Publication date: December 1, 2011

More about this publication?
  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Information for Advertisers
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more