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Open Access Chromatographic Fingerprinting Coupled with Chemometrics for Quality Control of Traditional Chinese Medicines

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The holistic system of traditional Chinese medicine (TCM) is reflected by the integrity of the ingredients contained in herbal medicines, which creates a challenge in establishing quality control standards for raw materials and the standardization of finished herbal drugs because no single component contributes to the total efficacy. Thus, the chromatographic fingerprinting technique of TCM has proved to be a comprehensive strategy for assessing the intact quality of herbal medicine, since the origin of the herbal medicines could be identified and classified based on so-called phytoequivalence. On the other hand, chromatographic fingerprinting is essentially a high-throughput technique and an integral tool to explore the complexity of herbal medicines. In order to further control the comprehensive quality of TCMs, some strategies are proposed to trace the chemical changes of chromatographic fingerprints both in product processing and/or after their administration by modern chromatographic techniques and chemometrics. Combined with the techniques developed in systems biology, it seems also possible to reveal the working mechanism of TCMs and to further control their intrinsic quality.

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Keywords: CHEMOMETRICS; CHROMATOGRAPHIC FINGERPRINTING; TRADITIONAL CHINESE MEDICINE

Document Type: Research Article

Affiliations: 1: Research Center of Modernization of Chinese Medicines Central South University Changsha 410083, China. [email protected] 2: Xinjiang Uygur Autonomous Region Institute for Food and Drug Control Urumqi, 830004, China

Publication date: December 1, 2011

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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