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Open Access Bicyclic Peptide Antagonists Derived from Genetically Encoded Combinatorial Libraries

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Ligands based on bicyclic peptides can combine favourable properties of antibodies (good binding affinity and target specificity) and small molecule ligands (stability, access to chemical synthesis, diffusion properties) and might be suitable molecular structures for the development of therapeutics. By using a combinatorial methodology based on phage display and a chemical cyclisation reaction, we are generating bicyclic peptide antagonists of protein targets with therapeutic applications in mind.

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Keywords: COMBINATORIAL CHEMISTRY; CYCLIC PEPTIDES; ENCODED LIBRARIES; PEPTIDE THERAPEUTICS; PHAGE DISPLAY; PROTEASE INHIBITORS; SERINE PROTEASES

Document Type: Research Article

Affiliations: Ecole Polytechnique Fédérale de Lausanne, EPFL, Institute of Chemical Sciences and Engineering, CH-1015 Lausanne

Publication date: September 1, 2011

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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