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Open Access High-Resolution and Tandem Mass Spectrometry – the Indispensable Tools of the XXI Century

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Mass spectrometry-based qualitative and quantitative (bio)molecular analysis is a corner stone in the state-of-the-art pipelines in systems biology and environmental sciences. High-resolution and efficient tandem mass spectrometry methods and techniques are the essential analytical capabilities for the in-depth analysis of extremely complex mixtures of (bio)molecules of a very broad dynamic range of concentrations. Here, we briefly review the advantages and limitations of the current mass spectrometry with a focus on resolution, or resolving power, and methods of (bio)molecular fragmentation in the gas phase. We conclude with an outlook that considers possible avenues for further mass spectrometry-based method and technique development, indispensable for advancing the challenging real-life mass spectrometry applications in the XXI century.

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Keywords: FOURIER TRANSFORM ION CYCLOTRON RESONANCE, FT-ICR; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY, MS; PEPTIDE; PETROLEOMICS; PROTEIN; PROTEOMICS; TANDEM MASS SPECTROMETRY, MS/MS

Document Type: Research Article

Affiliations: Biomolecular Mass Spectrometry Laboratory, Ecole Polytechnique Fédérale de Lausanne, EPFL LSMB BCH 4307, CH-1015 Lausanne

Publication date: September 1, 2011

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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