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Open Access In situ Product Recovery Integrated with Biotransformations

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Biocatalysis constitutes an effective tool for the production of fine chemicals. In order to widen the spectrum of applicable reaction types to reactions that are constrained by inhibitions, product toxicity, or degradation, an unfavorable position of the thermodynamic equilibrium, or by kinetic control, in situ product removal (ISPR) is an attractive process option to overcome those limitations. To fully exploit the benefits of the ISPR approach, selective removal of the product to an auxiliary phase with high capacity is usually required. Obviously, such an operation becomes increasingly difficult with decreasing differences in the physical properties of substrate(s) and product(s) as it is arguably frequently the case with biotransformations. In this paper we analyze the possibilities to apply ISPR to biotransformations and identify the most promising developments supported by simple model considerations to fully exploit the potential of ISPR.

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Keywords: BIOTRANSFORMATIONS; IN SITU PRODUCT REMOVAL; PRODUCT INHIBITION; PRODUCT TOXICITY; THERMODYNAMIC EQUILIBRIUM

Document Type: Research Article

Publication date: June 1, 2009

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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