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Open Access Targeting Posttranslational Modifications – Perspectives for Biocatalyst Engineering

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Engineering posttranslational modifications is of great importance in biomedical research. Recent advances in the field of biocatalyst engineering expanded the strategy of targeting posttranslational modifications to a novel research field, i.e. rendering the particular enzyme more efficient for the desired biocatalytic conversion. Thus enzymes could be trimmed to higher fitness for technical applications e.g. by improved activity and/or prolonged life-time. Furthermore, bottlenecks during enzyme expression caused by posttranslational processing in the cell can be overcome. Focusing especially on recent approaches in our laboratory, this article presents strategies for targeted manipulations of selected posttranslational modifications.

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Keywords: BIOCATALYSIS; HYDROXYNITRILE LYASE (HNL); N-GLYCOSYLATION; PICHIA PASTORIS; POSTTRANSLATIONAL MODIFICATION

Document Type: Research Article

Publication date: October 1, 2005

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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