Skip to main content
padlock icon - secure page this page is secure

Open Access Polymeric Nanoparticles for Drug Delivery to the Posterior Segment of the Eye

Download Article:
 Download
(PDF 753.9 kb)
 
Diseases of the posterior segment of the eye account for most cases of irreversible blindness worldwide. Drug delivery to this closed compartment remains a challenge because of the internal and external blood retinal barriers that selectively control drug penetration into the retina. Direct intraocular (intravitreal) delivery is currently used to achieve high drug concentration in the vitreous and the retina but is usually associated with several side effects. Alternatively topical, periocular, and systemic routes of administration can be used but are associated with low bioavailability and specific side effects. Therefore, intraocular sustained drug delivery systems are being designed to overcome these limitations. Polymeric nanoparticles loaded with therapeutic compounds are under investigation to provide new tools of administration to the eye. The first part of this paper will briefly review the barriers to ocular delivery of drugs and the advantages of using polymeric nanoparticle carriers as drug delivery systems. In the second part, the results in terms of preparation and characterization of polymeric nanoparticles loaded with nucleic acids, the study of the transretinal pathway of intravitreally injected nanoparticles and the assessment of their ability to efficiently deliver plasmids and oligonucleotides will be discussed.

36 References.

No Supplementary Data.
No Article Media
No Metrics

Keywords: DRUG DELIVERY SYSTEMS; EYE; GENE THERAPY; INTRAVITREAL ADMINISTRATION; NANOPARTICLES; RETINAL PIGMENT EPITHELIUM

Document Type: Research Article

Publication date: June 1, 2005

More about this publication?
  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Information for Advertisers
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more