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Open Access Cellular Assays with Multiparametric Bioelectronic Sensor Chips

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During recent years, sensor chip-based systems have been developed which monitor functional changes of living cells. Key elements of such cellular assays are silicon or glass chips with integrated sensors for physico-chemical parameters, i.e. pH, pO2, electric impedance and temperature. Analysis of these primary parameters yields information about cell metabolism, cell growth and adhesion, and cell morphological changes. The operation principles of individual sensor types are described together with examples of experimental results.

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Keywords: CELL MORPHOLOGY; CELL-BASED ASSAY; CELLULAR RESPIRATION; EXTRACELLULAR ACIDIFICATION; SENSOR CHIP

Document Type: Research Article

Publication date: May 1, 2005

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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