Skip to main content
padlock icon - secure page this page is secure

Open Access Pharmaceutical Biochemistry at the ETH Zürich

Download Article:
 Download
(PDF 1,130.9 kb)
 
Pharmaceutical biochemistry at the ETH Zürich is devoted to research on ligand–macromolecule interactions, combining experiments with computational data as closely as possible because we believe that there is no rational disease treatment without molecular understanding of events. For this purpose biochemical/biophysical studies of target proteins in complex with their ligands are an essential part of the research. Complementary and integrated to it, a second field of research is dedicated to computational methods that play an important role in drug discovery and development. These methods are strongly interconnected with the experiments and are used to generate new hypotheses to be tested experimentally. This approach has been made feasible by the progress of molecular biology and computer technology and is now extensively used in all major pharmaceutical industries and thus has to be taught to students. Because of the interdisciplinarity of the research a multidisciplinary environment has been established. The scientific effort of the group is focused on cancer and antiviral research. Key targets of the research are kinases, namely thymidine kinases and tyrosine kinases of oncogenic fusion proteins. In parallel and in view of the increasing amount of experimental data generated by the different -omics initiatives the group has started the development of appropriate software tools for data mining.

47 References.

No Supplementary Data.
No Article Media
No Metrics

Keywords: DRUG DESIGN; KINASES; LIGAND MACROMOLECULE INTERACTION; PROTEIN ENGINEERING; STEM CELLS

Document Type: Research Article

Publication date: October 1, 2004

More about this publication?
  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Information for Advertisers
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more