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Open Access Selective Synthesis of Fluorinated Compounds: Process Development and Preparation of Fluorinated Compounds from Gram up to Kilogram Scale

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The most versatile fluorination reactions for the preparation of up to kg amounts of fluorinated compounds are presented, i.e. the deoxofluorination of alcohols, oxo compounds and carboxylic acids using SF4, and the conversion of anilines to fluoro aromatics. Furthermore the enantioselective catalytic fluorination of β -ketoesters is highlighted. The option of outsourcing preparative fluorination is discussed.

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Document Type: Research Article

Publication date: March 1, 2004

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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