Focal Point: Medicinal Chemistry: A. Ligand-Receptor Interactions: From Understanding to Design
In his compelling style Hugo Kubinyi gave a comprehensive overview on ligand–receptor interactions. Besides teaching the basics, numerous examples coming from his rich and life-long experience in drug design pointed out both scope and limitations of the actual approaches in drug design.
Osman Güner from Accelrys was not able to come but was substituted by the European representative Remy Hofmann, who has longstanding experience in computational chemistry, especially focusing in the 3D-QSAR and pharmacophore description. His talk summarized the current approaches and provided insight in future developments which could soon facilitate categorization processes based on pharmacophoric properties for huge compound databases.
In the third talk, Leonardo Scapozza from the Institute of Pharmacy of the ETHZ delivered a fascinating and exciting research case from his lab. Based on the highly integrated technology mentioned above he designs therapeutic genes for application in cell-based therapy. By use of these 'genetic switches' one might be able in future to control graft-versus-host reactions after tissue transplants. Not only the protein, designed to avoid immune recognition and delivered via stem-cells, but also the adequate ligand has been designed to specifically interact on demand.
The end of the session was marked by Wolfgang Jahnke, showing us the exciting new applications of nuclear magnetic resonance methodology. Especially for detailed studies in the life sciences – recently acknowledged by the Nobel price granted to Kurt Wüthrich – NMR seems to develop as the ultimate technology.
Keywords: ANTIGEN PRESENTATION; BIOMOLECULAR NMR; CELL-BASED THERAPY; COMPUTATIONAL CHEMISTRY; COMPUTER-ASSISTED LIGAND DESIGN; DATABASE MINING; DRUG DESIGN; DRUG TARGETS; GENETIC SWITCH; LIGAND BINDING MODE; LIGAND-PROTEIN INTERACTIONS; NMR SCREENING; PHARMACOPHORE; REPORTER LIGAND; STEM CELLS; STRUCTURE-BASED DRUG DESIGN; SUICIDE GENE; THERAPEUTIC GENE; VIRTUAL LIBRARIES
Document Type: Research Article
Publication date: January 1, 2003
International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions
CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.
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