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Open Access Towards a Total Synthesis of Aminoacylated t-RNAs

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In the ribosomal biosynthesis of proteins, the aminoacylated t-RNAs serve as carriers of the amino acids. A total synthesis of these biological key-compounds would allow the site-specific incorporation of modifications within the t-RNA and attachment of any desired amino acid. Such analogues are useful tools for structural and functional studies, and for the incorporation of unnatural amino acids into proteins.

Our retrosynthetic scheme for the preparation of aminoacylated t-RNAs includes the synthesis of truncated t-RNAs, the synthesis of aminoacylated RNA-fragments, and their subsequent ligation. In this article, we present our approaches toward the realization of these three tasks.

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Keywords: LIGATION; OLIGONUCLEOTIDES; PROTECTING GROUPS; RNA SYNTHESIS; T-RNA

Document Type: Research Article

Publication date: January 1, 2001

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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