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Open Access Biotechnology in the Fine-Chemicals Industry: Cyclic Amino Acids by Enantioselective Biocatalysis

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Enantiomerically pure cyclic amino acids are of increasing interest for the life-science industry. To meet this demand, Lonza has developed biotransformation processes with emphasis on the integration of chemistry and biocatalysis for the production of homochiral proline, piperidine-2-carboxylic acid and piperazine-2-carboxylic acid, and valuable derivatives of these compounds. The processes are designed for use on industrial scale; they have been optimised with respect to availability and cost of starting materials and biocatalyst, productivity of the process and a feasible product isolation procedure. Because of the extraordinarily high enantioselectivity of the enzymes, the (R)- and the (S)-enantiomers of the unnatural cyclic amino acids, which are both of commercial interest, can be produced in a single reaction. The examples presented demonstrate the benefit from interdisciplinary research for the production of fine chemicals by the combination of chemistry and biotechnology.
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Document Type: Research Article

Publication date: December 1, 1999

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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