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Open Access E-cigarette Nicotine Delivery: Data and Learnings from Pharmacokinetic Studies

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Objectives: E-cigarettes could potentially play a major role in tobacco harm reduction by delivering nicotine in a vapor containing significantly fewer toxicants than cigarette smoke and may aid smoking behavior changes such as reduction or cessation. Methods: We examined blood nicotine levels in smokers who were non-accustomed to e-cigarette use (Study 1) and accustomed e-cigarette users (Study 2). We compared nicotine levels when participants used a closed modular system e-cigarette to those when participants smoked a cigarette. Results: In Study 1, Cmax (geometric mean (CV)) during a 5-minute puffing period (10 puffs, 30 seconds apart) was 13.4 (51.4%) ng/ ml for a regular cigarette. The e-cigarette Cmax was significantly lower (p < .05) at 2.5 (67.8%) ng/ml. In Study 2, during a 5-minute ad libitum puffing period, cigarette Cmax was 7.2 (130.8%) ng/mL, and it was 7.8 (108.2%) ng/mL for the e-cigarette. Conclusions: Our data demonstrate heterogeneity of nicotine deliveries both between products and also with the same products used by different cohorts, eg, accustomed users versus smokers. Such differences must be taken into account when determining the likely behavioral impact, on smoking reduction and cessation, of nicotine delivery data and when planning e-cigarette nicotine pharmacokinetic studies.

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Document Type: Research Article

Affiliations: 1: British American Tobacco (Investments) Limited, Research and Development, Southampton, United Kingdom (UK) 2: British American Tobacco (Investments) Limited, Research and Development, Southampton, UK 3: Los Angeles Clinical Trials, Burbank, CA, USA 4: British American Tobacco (Investments) Limited, Research and Development, Southampton, UK. [email protected]

Publication date: January 1, 2017

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  • The American Journal of Health Behavior seeks to improve the quality of life through multidisciplinary health efforts in fostering a better understanding of the multidimensional nature of both individuals and social systems as they relate to health behaviors.

    The Journal aims to provide a comprehensive understanding of the impact of personal attributes, personality characteristics, behavior patterns, social structure, and processes on health maintenance, health restoration, and health improvement; to disseminate knowledge of holistic, multidisciplinary approaches to designing and implementing effective health programs; and to showcase health behavior analysis skills that have been proven to affect health improvement and recovery.

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