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Current and future management of chronic spontaneous urticaria and chronic inducible urticaria

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Background:

Chronic urticaria (CU), characterized by ≥6 weeks of intense pruritus, remains a debilitating condition for patients. New and safe treatments are needed to manage CU recalcitrant to standard therapy.

Objective:

A review of the current literature of standard and novel therapeutics in the management of CU was conducted.

Methods:

A literature search via a medical literature data base and clinical trial data base was conducted to identify treatment options for CU and current clinical trials.

Results:

Second-generation antihistamines, omalizumab, and cyclosporine remain the most proven therapeutic options for CU. Dupilumab, mepolizumab, benralizumab, tezepelumab, and CDX-0159 are all undergoing clinical trials for CU. Although ligelizumab demonstrated initial promising results, a phase III study was discontinued due to a nonsuperior clinical impact compared with omalizumab.

Conclusion:

Novel therapies are needed for the treatment of recalcitrant CU. With a deeper understanding of the pathophysiology of CU, promising therapeutics are in clinical trials for CU.

Keywords: antihistamines; chronic spontaneous urticaria; dupilumab; omalizumab

Document Type: Research Article

Affiliations: 1: From the Department of Internal Medicine, Oregon Health and Science University, Portland, Oregon 2: Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, and 3: Section of Allergy and Clinical Immunology, Oregon Health and Science University, Portland, Oregon

Publication date: January 1, 2023

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

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    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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