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Free Content Liver enzyme elevation and normal pulmonary function in an adult with a declining forced expiratory volume in 1 second

This article presents a case report of a 41-year-old male firefighter with cholecystitis and a history of mildly elevated alanine aminotransferase. Liver biopsy showed periodic acid Schiff–positive, diastase-resistant periportal globules. Retrospective review of clinical data revealed progressive lung function decline despite absent pulmonary symptoms and normal pulmonary function testing. The following disorders should be considered in any patient with elevated transaminases without an apparent etiology: viral hepatitides, medication toxicity, autoimmune hepatitis, alcohol-induced hepatic injury, and alpha-1-antitrypsin deficiency.

Keywords: Adult; Mmalton; alpha-1-antitrypsin; asymptomatic; hepatitis; liver enzymes; presymptomatic; pulmonary function; transaminases

Document Type: Regular Paper

Affiliations: Division of Allergy and Immunology, The Pennsylvania State University Milton S. Hershey Medical Center, Hershey Pennsylvania

Publication date: May 1, 2008

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