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Open Access Mental disorders and drug/alcohol use in patients commencing extensively drug-resistant tuberculosis treatment

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Mental disorders and alcohol/drug use worsen treatment outcomes for multidrug-resistant tuberculosis (TB), but data are lacking for extensively drug-resistant (XDR) TB. We investigated the association of baseline mental disorders and alcohol/drug use on XDR-TB treatment outcomes in a retrospective study of 53 XDR-TB Peruvian patients during 2010–2012. Logistic regression estimated the odds ratios for unfavourable XDR-TB treatment outcomes. Overall treatment success was 25%. Mental disorders and drug/alcohol use were found in respectively 22.4% and 20.4% of patients; neither were associated with unfavourable treatment outcomes. Future research should explore the relationship between mental health and drug/alcohol use in XDR-TB treatment outcomes.
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Keywords: XDR-TB; alcohol; anxiety; depression; psychosis

Document Type: Short Communication

Affiliations: 1: Epsom and St Helier University Hospitals NHS Trust, London, UK 2: Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK 3: Socios En Salud, Lima, Peru 4: Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA 5: Socios En Salud, Lima, Peru, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA

Publication date: September 21, 2017

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  • Public Health Action (PHA), The Union's quarterly open access on-line journal, provides a platform for its mission 'Health solutions for the poor'. PHA addresses the need for show-casing operational research that addresses issues in health systems and services. It publishes high-quality scientific research that provides new knowledge to improve access, equity, quality and efficiency of health systems and services.

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