
Therapeutic drug monitoring and TB treatment outcomes in patients with diabetes mellitus
METHODS: To compare treatment outcomes in programs with routine TDM vs. programs that did not use TDM, we conducted a retrospective study among people with DM and TB at health departments in four US states.
RESULTS: A total of 170 patients were enrolled (73 patients in the non-TDM group and 97 patients in the TDM group). Days to sputum culture conversion and total treatment duration were significantly shorter in the TDM group vs. the non-TDM group. In adjusted analyses, patients who underwent TDM were significantly more likely to achieve sputum culture conversion at 2 months (P = 0.007).
CONCLUSION: TDM hastened microbiological cure from TB among people with DM and a high risk for poor treatment outcomes in the programmatic setting.
Keywords: DM; TB; sputum culture conversion; therapeutic drug monitoring; treatment outcomes
Document Type: Research Article
Affiliations: 1: Medical University of South Carolina, Charleston, SC, USA 2: Tennessee Department of Health, Nashville, TN, USA 3: New Mexico Department of Health, Santa Fe, NM, USA 4: Virginia Department of Health, Richmond, VA, USA 5: Arizona Department of Health Services, Phoenix, AZ, USA 6: University of Florida, Gainesville, FL, USA 7: University of Virginia, Charlottesville, VA, USA
Publication date: February 1, 2023
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