Prevalence and clinical characteristics of pulmonary TB among pregnant and post-partum women
OBJECTIVE: To estimate the prevalence of TB among pregnant and post-partum women and describe the clinical characteristics of the disease in a rural area of Southern Mozambique.
METHODS: We conducted a cross-sectional TB prevalence study among pregnant and post-partum women recruited from September 2016 to March 2018 at the Manhiça Health Care Center (MHC). We recruited two independent cohorts of women consecutively presenting for routine pregnancy or post-partum follow-up visits.
RESULTS: A total of 1,980 women from the ANC clinic and 1,010 from the PPC clinic were enrolled. We found a TB prevalence of 505/100,000 (95% CI: 242–926) among pregnant women and 297/100,000 (95% CI: 61–865) among post-partum women. Among HIV-positive pregnant women, TB prevalence was 1,626/100,000 (95% CI: 782–2,970) and among postpartum HIV-positive women, TB prevalence was 984/100,000 (95% CI: 203–2,848).
CONCLUSIONS: The burden of TB was not higher in postpartum women than in pregnant women. Most TB cases were detected in HIV-positive women. TB screening and diagnostic testing among pregnant and postpartum women attending ANC and PPC clinics in Manhiça District is acceptable and feasible.
Keywords: Mozambique; epidemiology; postpartum; pregnancy; tuberculosis
Document Type: Research Article
Affiliations: 1: Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique 2: ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain 3: Fundação Ariel Glaser contra o SIDA Pediátrico, Maputo, Mozambique 4: Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique, ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain 5: ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain, Agència de Salut Pública de Barcelona, Barcelona, Spain, Institut d´Investigació Biomèdica Sant Pau, Barcelona, Spain 6: Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA, Vanderbilt Tuberculosis Center, Vanderbilt University Medical Center, Nashville, TN, USA 7: Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA 8: Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA, Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA 9: Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique, ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain
Publication date: July 1, 2022
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