A self-rated health score predicts severe disease and high mortality in patients with pulmonary TB
AIMS: To evaluate internal and external validity of SRH and its correlation with TBscore/TBscoreII in a low-resource setting.
METHODS: We used data from our ongoing prospective TB cohort study in Guinea-Bissau. Cohen´s d was used to assess internal validity, and receiver-operating characteristics and mortality statistics to assess external validity. Correlation between SRH and TBscore/TBscoreII was estimated using linear regression.
RESULTS: SRH showed satisfactory internal validity and ability to discriminate between fatal cases at high and low scores, although not at middling scores. SRH and TBscore/TBscoreII correlated well at each examination but changes in scores did not, which may be due to ceiling/floor effects and a lag between disease severity and HRQoL.
CONCLUSION: SRH shows potential as a quick and simple method to identify patients in need of intensified follow-up during treatment provision. More research is needed to assess its generalisability beyond our setting and to develop models for clinical use of SRH.
Keywords: HRQoL; SRH; TBscore/TBscoreII; health-related quality of life; low-income settings; self-rated health
Document Type: Research Article
Affiliations: 1: Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau, Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark, GloHAU, Center for Global Health, Department of Public Health, Aarhus University, Aarhus, Denmark 2: Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau, GloHAU, Center for Global Health, Department of Public Health, Aarhus University, Aarhus, Denmark 3: Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau 4: Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau, Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
Publication date: February 1, 2022
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