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Epidemiological and spatial factors for tuberculosis: a matched case-control study in Nagata, Japan

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SETTING AND OBJECTIVE: Several studies have found a significant association between tuberculosis (TB) and spatial factors. We wished to determine the effect of host-related factors and spatial factors associated with an increased risk of TB, and to assess spatial clustering.

DESIGN: A hospital-based case-control study using medical records was conducted. A total of 103 age- and sex-matched TB patients (cases) and 299 patients without TB (controls) were recruited from January 2000 to December 2016 in a hospital in Nagata, Kobe, Japan. Logistic regression, kernel density estimation, Cross L function and a Poisson regression model were applied.

RESULTS: The epidemiological factors associated with TB were being a health care worker (OR 10.1) and lower serum albumin level (OR 0.5). Spatial analyses revealed TB to be positively associated with population density (risk ratio [RR] 32.1), the proportion of single households (RR −1.85) and persons aged 65 years (RR 2.65) and one spatial clustering.

CONCLUSION: Our findings could help in the identification of high TB risk individuals and districts.

Keywords: Japan; TB; risk factors; spatial factors

Document Type: Research Article

Affiliations: 1: Department of Public Health, Graduate School of Health Sciences, Kobe University, Hyogo 2: Department of Internal Medicine, Kobe Kyodo Hospital, Hyogo, Japan

Publication date: February 1, 2019

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  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

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