Drug resistance in extra-pulmonary tuberculosis in South Korea: comparison with pulmonary tuberculosis
METHODS: We retrospectively analysed the results of phenotypic drug susceptibility testing (DST) in culture-confirmed TB patients from January 2010 to December 2014 at seven university hospitals in South Korea.
RESULTS: Of 5599 patients included, 320 (5.7%) were classified in the EPTB group and 5279 (94.3%) in the PTB group. The proportion of EPTB among all TB cases had gradually increased from 2010 to 2014 (P = 0.004). Among both new and previously treated patients, there were no significant differences in rates of resistance to any kind of anti-tuberculosis drug between the EPTB and PTB groups. The trends in drug resistance rates among new patients were similar in both the EPTB and PTB groups. The rates of multidrug-resistant TB among new patients gradually decreased in both groups (P = 0.031 and P = 0.001, respectively).
CONCLUSION: The prevalence of and trends in drug resistance among new patients are not significantly different between patients with EPTB and those with PTB.
Keywords: EPTB; South Korea; TB; pulmonary; resistance
Document Type: Research Article
Affiliations: 1: Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan 2: Department of Internal Medicine, Dong-A University Hospital, Busan 3: Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan 4: Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju 5: Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 6: Department of Internal Medicine, Inje University Busan Paik Hospital, Busan 7: Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea
Publication date: 01 February 2019
This article was made available online on 08 January 2019 as a Fast Track article with title: "Drug resistance in extra-pulmonary tuberculosis in South Korea: comparison with pulmonary tuberculosis".
The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.
The IJTLD is dedicated to understanding lung disease and to the dissemination of knowledge leading to better lung health. To allow us to share scientific research as rapidly as possible, the IJTLD is fast-tracking the publication of certain articles as preprints prior to their publication. Read fast-track articles.
- Editorial Board
- Information for Authors
- Subscribe to this Title
- International Journal of Tuberculosis and Lung Disease
- Public Health Action
- Ingenta Connect is not responsible for the content or availability of external websites
Receive new issue alert- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content