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Home / The International Journal of Tuberculosis and Lung Disease, Volume 20, Supplement 1

Open Access Elucidating the role of clofazimine for the treatment of tuberculosis

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Clofazimine (CFZ), a riminophenazine and a key component of the treatment regimen for lepromatous leprosy, has been rehabilitated clinically for the treatment of multidrug-resistant tuberculosis (MDR-TB). Observational studies and a randomized control trial suggest efficacy in the treatment of MDR-TB and the potential for treatment shortening. Animal and translational research have shown mixed results. In this article, we review key clinical, animal, and translational data to better understand the potential role of CFZ in the treatment of MDR-TB and in shortening anti-tuberculosis treatment.

Keywords: CFZ; TB; treatment

Document Type: Research Article

Affiliations: 1: Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York City, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York City, New York, USA; CAPRISA MRC-HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa 2: CAPRISA MRC-HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa 3: Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA

Publication date: 01 December 2016

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  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

    The IJTLD is dedicated to understanding lung disease and to the dissemination of knowledge leading to better lung health. To allow us to share scientific research as rapidly as possible, the IJTLD is fast-tracking the publication of certain articles as preprints prior to their publication. Read fast-track articles.

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