Skip to main content
padlock icon - secure page this page is secure

Open Access Elucidating the role of clofazimine for the treatment of tuberculosis

Download Article:
 Download
(PDF 83 kb)
 
Clofazimine (CFZ), a riminophenazine and a key component of the treatment regimen for lepromatous leprosy, has been rehabilitated clinically for the treatment of multidrug-resistant tuberculosis (MDR-TB). Observational studies and a randomized control trial suggest efficacy in the treatment of MDR-TB and the potential for treatment shortening. Animal and translational research have shown mixed results. In this article, we review key clinical, animal, and translational data to better understand the potential role of CFZ in the treatment of MDR-TB and in shortening anti-tuberculosis treatment.
No Reference information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: CFZ; TB; treatment

Document Type: Research Article

Affiliations: 1: Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York City, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York City, New York, USA; CAPRISA MRC-HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa 2: CAPRISA MRC-HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa 3: Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA

Publication date: December 1, 2016

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more