Clinical characteristics and outcomes of tuberculosis in Douala, Cameroon: a 7-year retrospective cohort study
OBJECTIVE: To describe the clinical characteristics of TB and to investigate predictors of poor treatment outcomes.
DESIGN: A registry-based, retrospective cohort study of all TB cases recorded from 2007 to 2013 was conducted. Multinomial logistic regression models were used to identify predictors of poor outcomes.
RESULTS: Of 8902 TB cases included, 5110 (57.4%) were males. The median age was 33 years. The prevalence of human immunodeficiency virus (HIV) infection was 37.6%, with a significant decline over the study years (P = 0.000). The main clinical form of TB was smear-positive TB (50.5%). The treatment success rate was 75.2%, while the mortality rate was 8.1%. The year of TB diagnosis, retreatment cases, sputum non-conversion at the end of month 2, HIV infection and HIV testing not done were associated with death. Retreatment and non-conversion of sputum were associated with treatment failure, while male sex, age, sputum non-conversion, HIV infection and HIV testing not done were associated with loss to follow-up.
CONCLUSION: TB management objectives may be attained by focusing specifically on higher risk groups to prevent poor treatment outcomes.
Document Type: Research Article
Affiliations: 1: Department of Internal Medicine, Douala General Hospital, Douala, Cameroon; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon 2: Department of Internal Medicine, Douala General Hospital, Douala, Cameroon 3: Respiratory Diseases Unit, Douala Laquintinie Hospital, Douala, Cameroon 4: Faculty of Health Sciences, University of Bamenda, Bamenda, Cameroon
Publication date: December 1, 2016
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