Impact of contact investigation and tuberculosis screening among high-risk groups in Denmark
METHODS: ACF patients were identified by screening socially marginalised persons or through contact investigation. Logistic regression was used to model the associations between case-finding group (ACF/PCF) and hospitalisation, and between case-finding group and smear positivity rates.
RESULTS: A total of 108 patients were identified through ACF and 332 through PCF. Thirty (27.8%) ACF patients and 153 (46.1%) PCF patients were hospitalised. In the adjusted models, ACF patients (OR 0.24, P < 0.001) and ACF subgroups identified using mobile X-ray screening, spot sputum culture screening and contact investigation were significantly less likely to be hospitalised than PCF patients. Thirty-one (34.4%) ACF patients and 127 (50.4%) PCF patients were smear-positive. ACF patients (OR 0.30, P < 0.001) and ACF subgroups identified through contact investigation and spot sputum culture screening were less likely to be smear-positive than PCF patients.
CONCLUSIONS: These findings suggest that ACF reduces morbidity and infectiousness among TB patients, thereby potentially improving health outcomes and reducing transmission of M. tuberculosis.
Document Type: Research Article
Affiliations: 1: Department of Respiratory Medicine, Gentofte University Hospital, Copenhagen, Denmark; Department of Pulmonary and Infectious Diseases, Gentofte University Hospital, Copenhagen, Denmark 2: International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark 3: Departments of Respiratory Medicine, Gentofte University Hospital, Copenhagen, Denmark 4: Department of Infectious Disease Epidemiology, Statens Serum Institut, Copenhagen, Denmark
Publication date: December 1, 2016
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