Skip to main content
padlock icon - secure page this page is secure

Free Content Increased risk of pulmonary tuberculosis in patients with gastroesophageal reflux disease

Download Article:
 Download
(PDF 222.1 kb)
 
BACKGROUND: Previous studies have suggested a close correlation between gastroesophageal reflux disease (GERD) and various respiratory disorders. However, the association between GERD and tuberculosis (TB) remains unexplored.

METHODS: Using data retrieved from Taiwan's National Health Insurance Research Database from 2000 to 2009, this longitudinal nationwide cohort study included a total of 63 930 patients with GERD and controls matched by age, sex and comorbidities. Risk factors associated with the development of pulmonary TB (PTB) were investigated.

RESULTS: Active PTB was documented in 65 (0.20%) patients with GERD and 41 (0.13%) matched cohorts within 1 year of GERD diagnosis. The incidence rate of PTB in the GERD group and the matched cohort was respectively 24.1 and 15.2 cases per 10 000 person-years. In multivariate analysis, GERD was an independent risk factor for PTB (adjusted HR 1.63, 95%CI 1.10–2.40, P = 0.015). Among patients with GERD, independent predictors for PTB included older age, male sex, chronic obstructive pulmonary disease, asthma and exposure to proton pump inhibitors (PPIs).

CONCLUSION: Patients with GERD have a significantly increased risk of PTB within 1 year of GERD diagnosis. Exposure to PPIs is an independent predictor for PTB among patients with GERD.
No Reference information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: GERD; TB; proton pump inhibitors; risk factors

Document Type: Research Article

Affiliations: 1: *Division of Infectious Disease, Department of Medicine, Taipei Veterans General Hospital, Taipei, School of Medicine, National Yang-Ming University, Taipei 2: School of Medicine, National Yang-Ming University, Taipei, Division of Nephrology, Department of Medicine 3: School of Medicine, National Yang-Ming University, Taipei, §Department of Chest Medicine, Taipei Veterans General Hospital Taipei, Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei 4: School of Medicine, National Yang-Ming University, Taipei, #Cancer Center, Taipei Veterans General Hospital, Taipei, **Institute of Public Health, National Yang-Ming University, Taipei 5: ††Department of Family Medicine, Taipei Veterans General Hospital, Taipei 6: School of Medicine, National Yang-Ming University, Taipei, §Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 7: School of Medicine, National Yang-Ming University, Taipei, ‡‡Department of Psychiatry, Kaoshiung Veterans General Hospital, Kaoshiung 8: School of Medicine, National Yang-Ming University, Taipei, §§Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan 9: School of Medicine, National Yang-Ming University, Taipei, **Institute of Public Health, National Yang-Ming University, Taipei, §§Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

Publication date: February 1, 2016

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more