Incidence of toxic optic neuropathy with low-dose ethambutol
DESIGN: Patients diagnosed with TB or MAC lung disease received multidrug regimens including EMB at a single institution from August 2003 to July 2009. Visual monitoring was performed at baseline and at regular follow-up. The incidence of EMB-induced visual disturbances was evaluated.
RESULTS: Of the 415 patients included in the study, three (0.7%) developed toxic optic neuropathy over the 6-year period. Of the 289 patients prescribed a dose of 15 mg/kg/day EMB, only one (0.3%) developed toxic optic neuropathy.
CONCLUSIONS: The incidence of EMB-induced optic neuropathy among Koreans is estimated to be 0.7%, and can be reduced with lower doses of EMB.
Document Type: Research Article
Affiliations: 1: *Department of Ophthalmology, and 2: †Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
Publication date: February 1, 2016
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