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Free Content Changes in lung function according to disease extent before and after pulmonary tuberculosis

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OBJECTIVE: To evaluate changes in lung function in individuals before and after treatment for pulmonary tuberculosis (PTB) in relation to extent of disease.

DESIGN: Using a retrospective cohort design, changes in and predictors of lung function were evaluated.

RESULTS: A total of 41 patients were included in the final analysis. The median decline in annualised forced expiratory volume in 1 sec (FEV1) was 180.0 ml/year (95%CI 118.9–356.1) in advanced PTB and 94.7 ml/year (95%CI 33.4–147.3) in localised PTB (ΔFEV1 % predicted/year 9.4%, 95%CI 4.4–14.0 vs. 3.8%, 95%CI 1.8–6.2). The median decline in annualised forced vital capacity (FVC) was 309.6 ml/year (95%CI 137.0–359.0) in advanced PTB and 101.1 ml/year (95%CI 30.3–219.6) in localised PTB (ΔFVC % predicted/year 7.3%, 95%CI 5.3–12.3 vs. 2.9%, 95%CI 0.9–6.5).

CONCLUSIONS: As the sample size of our study was small, the conclusions could be biased. Nevertheless, our findings show that PTB causes a significant decline in lung function even in localised PTB, whereas advanced PTB was associated with excessive or even higher decline. This study suggests that early diagnosis and treatment of PTB is needed to preserve lung function.
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Keywords: Mycobacterium tuberculosis; impairment; lung function decline; pulmonary function

Document Type: Research Article

Affiliations: 1: *Department of Pulmonary and Critical Care Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, 2: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, 3: Division of Pulmonary Medicine, CHA University School of Medicine, Gumi CHA Hospital, Gumi, 4: §Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Dankook University Hospital, Cheonan, 5: Department of Radiology, and 6: #Department of Pharmacology and Pharmaco Genomics Research Center, Inje University College of Medicine, Busan, Republic of Korea

Publication date: May 1, 2015

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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