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Free Content Multidrug-resistant tuberculosis in the United Kingdom and Lithuania

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Rates of resistance to first- and second-line drugs in multidrug-resistant tuberculosis (MDR-TB) cases in the United Kingdom were studied during 2010–2012. The highest rates for ethambutol, pyrazinamide and aminoglycosides occurred among patients originating in Eastern Europe, of whom 47% were Lithuanian. Rates of resistance to kanamycin were significantly lower (P < 0.0001) in the Lithuanian National TB Register than among Lithuanian patients resident in the United Kingdom (5% vs. 78%). In 2010, the majority of UK patients of Eastern European origin were located within the London region, whereas in 2011 the majority were located outside this region, a significant change (P = 0.01).
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Keywords: MDR-TB; XDR-TB; aminoglycoside resistance; drug susceptibility testing

Document Type: Research Article

Affiliations: 1: National Mycobacterium Reference Laboratory, Barts and the London, Queen Mary's School of Medicine, London, UK 2: Infectious Diseases and Tuberculosis Hospital, Santariskiu Klinikos, Affiliate of Vilnius University Hospital, Vilnius, Lithuania

Publication date: June 1, 2014

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on lung health world-wide.

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